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SKIN CORROSION : Human skin Model test OECD 431

OECD 431

PRINCIPLE OF THE TEST

The test material is applied topically to a three-dimensional human skin model, comprising at least a reconstructed epidermis with a functional stratum corneum. Corrosive materials are identified bytheir ability to produce a decrease in cell viability [as determined, for example, by using the MTT reduction assay below defined threshold levels at specified exposure periods. The principle of the human skin model assay is based on the hypothesis that corrosive chemicals are able to penetrate the stratum corneum by diffusion or erosion, and are cytotoxic to the underlying cell layers.

OCDE 439 epidermis_in_vitro_r-2

Price

€€

Turnaround

4 weeks

€ : < 1500 € €€ : between 1500 and 4000 € €€€ : between 4000 and 20000 € €€€€ : > 20000 €
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