ASSESSMENT OF SENSITING PROPERTIES ON GINEA PIGS : ACCORDING TO BUEHLER

OECD 406

 Similar to the sensitisation test according Magnusson and Kligman, it is a non-adjuvant test.

It does not involved any intradermal injection but only topical application.

In the test, Guinea pigs are exposed to a high dose of the substance (3-6 or 9 topical applications).

They are then given a challenge dose, which is the highest dose that does not cause irritation.

*Done with partner

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