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Safety Pharmacology

Since 2008, PHYCHER proposes safety pharmacology tests, in compliance with GLP.

CENTRAL NERVOUS SYSTEM
GUIDELINE STUDY TIMEFRAME
ICH S7A Neurobehavioural observation test : Irwin test 3 weeks
ICH S7A Motor coordination : Rotarod test 3 weeks
ICH S7A Proconvulsant effet 3 weeks
ICH S7A Effects on vigilance : hexobarbital-induced sleeping time 3 weeks

 

GASTRO-INTESTINAL SYSTEM 
ICH S7A Charcoal transit time 3 weeks
ICH S7A Gastric emptying and secretion (solid or liquid) 3 weeks
ICH S7A Ulcerogenic effect 3 weeks

 

ANALGESIA / COAGULATION 
ICH S7A Central analgesia : Hot Plate test 3 weeks
ICH S7A Central and peripheral analgesia : Randall and Selitto test 4 weeks
ICH S7A Anti inflammatory effect : Paw oedema volume 3 weeks
ICH S7A Bleeding time 3 weeks
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